MMP-9和PTEN在乳腺癌中的表达及其临床意义Expression and clinical significance of MMP-9 and PTEN in the tissues of breast cancer
师晓莉;刘存;
摘要(Abstract):
目的:探讨基质金属蛋白酶-9(MMP-9)和PTEN在乳腺癌中的表达及其临床意义。方法:运用免疫组化Envision方法检测56例乳腺癌和22例乳腺良性病变中(乳腺腺病和乳腺腺瘤各11例)MMP-9和PTEN的表达情况,并分析其与临床病理参数的关系。结果:(1)MMP-9在乳腺癌中的阳性率为69.64%(39/56),在乳腺良性病变中的阳性率为45.45%(10/22);PTEN在乳腺癌中高表达率为46.43%(26/56),在乳腺良性病变中为86.36%(19/22),两组差异有统计学意义(P<0.05)。(2)MMP-9的表达与组织学分级和腋窝淋巴结转移呈正相关。PTEN蛋白的表达与腋窝淋巴结转移呈负相关,而与组织学分级无关(P>0.05)。结论:(1)MMP-9参与乳腺癌的发生发展过程,可作为评估乳腺癌浸润和转移的重要生物学指标。(2)乳腺癌中存在PTEN蛋白表达异常,可能与乳腺癌的发生、发展和预后有关。
关键词(KeyWords): 乳腺癌;基质金属蛋白酶-9;PTEN蛋白;免疫组织化学
基金项目(Foundation):
作者(Author): 师晓莉;刘存;
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参考文献(References):
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