猪原位肝移植围术期血流动力学及生化代谢变化的研究A research on hemodynamic and biochemico metabolic changes during orthotopic liver transplantation in pigs
郑宏,徐志新,洪毅,任新英,曹兴华,李亦梅,姜素,朱有森,尹极峰,温浩
摘要(Abstract)：
目的 :在体外静脉 -静脉转流下行原位猪肝移植术 ,观察围术期血流动力学及生化代谢和小剂量多巴胺、硝普钠对肾功能的保护作用。 方法 :随机选择健康杂种猪 16头 ,静脉复合麻醉下 ,经右颈外静脉插入 Swan-Ganz导管监测血流动力学 ,自右颈内动脉和颈外静脉采血监测血气和血生化。无肝期采用门静脉与股静脉 Y型连接后 ,再与左颈外静脉连接 ,进行体外静脉 -静脉转流。无肝前期小剂量多巴胺、硝普钠静脉联合用药并观察尿量。结果 :无肝期和新肝期血流动力学变化剧烈并伴有代谢性酸中毒 ;血清 K+ 在新肝期有一过性升高 ;未出现少尿或无尿。结论 :原位肝移植术中即使应用体外静脉 -静脉转流术仍有血流动力学、酸碱及电解质的显著变化 ,小剂量多巴胺与硝普钠联合应用有助于肾功能维护。
关键词(KeyWords)： 肝移植;血流动力学;血生化;肾功能
基金项目(Foundation): 自治区科委资助! ( 990 10 3 0 0 4)
作者(Author): 郑宏,徐志新,洪毅,任新英,曹兴华,李亦梅,姜素,朱有森,尹极峰,温浩
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参考文献(References)：
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