乳腺浸润性导管癌中E-cadherin、cyclin D_1、Ki-67的表达及其意义Expression of E-cadherin, cyclin D_1 and Ki-67 in invasive ductal carcinoma of breast and its significance
刘桂桃;刘存;蔡婷婷;师晓莉;张静;
摘要(Abstract)：
目的:探讨乳腺浸润性导管癌中表皮钙粘蛋白E-cadherin(E-cad)、细胞周期素D1(cyclinD1)、Ki-67蛋白的表达及其临床病理意义。方法:用免疫组织化学EnVision二步法分别检测63例乳腺浸润性导管癌(IDC)组织(IDC组)及15例乳腺纤维腺瘤及15例乳腺小叶增生症乳腺组织(对照组)中E-cad、cyclinD1、Ki-67蛋白的表达情况,结果:E-cad在IDC组及对照组中表达阳性率分别为58．3％、80％;cyclinD1在IDC组及对照组中表达阳性率分别为68．25％、0;Ki-67在IDC组及对照组中表达阳性率分别为65．08％、0。2组间差异均有统计学意义(P <0．05)。E-cadherin、cyclinD1、Ki-67的表达与患者年龄及肿块大小无关,E-cadherin、cyclinD1的表达与组织学分级、淋巴结转移相关。结论:E-cad、cyclinD1、Ki-67表达在乳腺癌发生、发展演进过程中是一个重要指标。联合检测E-cadherin、cyclinD1、Ki-67蛋白对预测乳腺癌发生、发展及淋巴结转移有重要意义。
关键词(KeyWords)： 乳腺浸润性导管癌;E-钙粘蛋白;细胞周期素D1;Ki-67;免疫组织化学
基金项目(Foundation):
作者(Author): 刘桂桃;刘存;蔡婷婷;师晓莉;张静;
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参考文献(References)：
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