姚雪萍,张建龙,龙梅,马琪,冉新健

• 1:新疆医科大学基础医学院机能中心

摘要(Abstract)：

目的观察脓毒血症大鼠血清中TNF-α、IL-1含量,初步探讨黑木耳对脓毒血症的影响。方法健康Wistar大鼠随机分为4组,对照组、实验组、思密达组、黑木耳多糖组,术前灌胃3d,第4d行手术,除对照组只翻动盲肠不结扎外,其余均结扎盲肠穿刺,术后随时观察大鼠的一般状况,造模12h后处死大鼠,腹主动脉取血,分光光度计检测血清内毒素含量;血气分析,ELISA法检测血清中TNF-α、IL-1含量。结果对照组血清内毒素、TNF-α、IL-1、PaO2、PaCO2、与实验组比较,差异均有统计学意义(P<0.05),思密达组内毒素、TNF-α、IL-1、与对照组、实验组差异均有统计学意义(P<0.05),黑木耳多糖组内毒素、TNF-α、IL-1与对照组、实验组差异均有统计学意义(P<0.05)。结论黑木耳粗提物能显著降低脓毒症大鼠血清中内毒素、TNF-α、IL-1含量。

关键词(KeyWords)： 黑木耳;脓毒症;TNF-α;IL-1

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 姚雪萍,张建龙,龙梅,马琪,冉新健

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