张明帅,朱丽萍,齐新,赵倩,吐鲁洪·沙比尔,倪多,张国庆

• 1:新疆医科大学附属肿瘤医院乳腺外科

摘要(Abstract)：

目的探讨新疆维、汉民族乳腺良恶性组织中Anexelekto(Axl)及其配体生长停滞特异性基因6蛋白(Growtharrest specific gene 6,Gas6)的表达及其临床病理意义。方法选择2006年1月-2007年1月新疆医科大学附属肿瘤医院乳腺外科收治的Ⅰ~Ⅲ期可手术且临床及病理资料完整的乳腺癌患者252例及乳腺良性增生21例,用免疫组化PV-9000法检测Axl及其配体Gas6的表达情况,分析其表达情况与临床病理指标的关系。结果在乳腺癌组织中Axl蛋白的阳性表达率为63.5%,明显高于正常对照组织的28.6%,差异有统计学意义(P<0.05);Gas6在癌组织的阳性表达率为47.6%,明显高于正常对照组织的23.8%,差异有统计学意义(P<0.05)。不同民族、不同年龄组、不同病理类型及不同分子分型组间Axl和Gas6蛋白的阳性表达率差异无统计学意义(P>0.05);Axl和Gas6蛋白的阳性表达率随着肿瘤T分期及组织学分级的增高而增高,差异均具有统计意义(P<0.05);在淋巴结有转移组的Axl和Gas6蛋白的阳性表达率分别为70.4%、56.3%,明显高于淋巴结无转移组的50.9%和36.4%,差异有统计学意义(P<0.05);在脉管有浸润组的Axl和Gas6蛋白的阳性表达率也明显高于无浸润组,差异有统计学意义(P<0.05)。结论新疆维、汉民族良恶性病变组织中Axl、Gas6的表达水平与肿瘤的T分期、组织学分级、腋窝淋巴结转移及脉管浸润有密切关系。

关键词(KeyWords)： 乳腺肿瘤;肿瘤转移;维吾尔族;Axl;Gas6

Abstract:

Keywords:

基金项目(Foundation): 新疆维吾尔自治区高等学校科研计划(重点)项目(XJEDU2010I38);; 新疆医科大学科研创新基金(XJC201160)

作者(Author): 张明帅,朱丽萍,齐新,赵倩,吐鲁洪·沙比尔,倪多,张国庆

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