P66shc基因多态性及单体型与和田维吾尔族长寿人群肾功能衰退的关系研究Research on relationship between longevity in Hetian Uygur population and polymorphisms and haplotypes of the P66shc gene
李素华,徐新娟,梁晓慧,张俊仕,孙理华
摘要(Abstract)：
目的探讨P66shc基因rs8191981、rs4845401位点多态性与和田维吾尔族长寿人群肾功能衰退的关系。方法采用多重SNaPshot方法对在65例肾功能减退(病例组)和47例肾功能正常者(对照组)的P66shc基因rs8191981、rs4845401位点多态进行基因分型。结果病例组和对照组P66shc基因rs8191981、rs4845401位点的基因型频率、等位基因频率及单体型分布差异均无统计学意义(P>0.05);与长寿老人肾功能减退的关联分析显示:P66shc基因所测位点多态性与维吾尔族长寿老人肾功能减退不相关(P>0.05)。结论 P66shc基因rs8191981、rs4845401位点多态可能与新疆维吾尔族长寿人群肾功能减退无关。
关键词(KeyWords)： P66shc基因;肾功能减退;多态性
基金项目(Foundation): 国家自然科学基金项目(30860296);; 新疆维吾尔自治区心血管病研究重点实验室开放课题项目(XJDX0903-2009-06)
作者(Author): 李素华,徐新娟,梁晓慧,张俊仕,孙理华
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