赵春梅,刘慧,王彦焱,孟岩,古丽仙,张新玉,贾娜,罗莉

• 1:新疆医科大学第一附属医院风湿科
• 2:新疆医科大学第一附属医院口腔颌面部肿瘤外科

摘要(Abstract)：

目的探讨抗核糖体P蛋白抗体(Ribosomal Pantibodies,anti-P)在新疆青少年系统性红斑狼疮(Ju-venile SLE)患者中的临床意义。方法无选择性连续收集2007—2012年79例青少年系统性红斑狼疮患者,其中34例anti-P阳性和45例anti-P阴性青少年SLE患者,两组进行前瞻性病例对照研究,分析比较两组临床特征、自身抗体和治疗方面的差异。结果与anti-P阴性组相比,anti-P阳性组患者发病时年龄较小,关节炎和神经精神狼疮(Neuropsychiatric SLE,NPSLE)的发生率明显升高,差异具有统计学意义(P<0.05),anti-P阳性组患者病情活动指数高于anti-P阴性组,差异具有统计学意义(P<0.05)。与anti-P阴性组相比,anti-P阳性组患者血清中抗aCL抗体阳性率较高(P<0.05)。两组种族、性别、狼疮肾炎及其他临床表现和自身抗体比较,差异无统计学意义(P>0.05)。Anti-P阳性组患者环磷酰胺使用率高于anti-P阴性组(P<0.05)。NPSLE患者主要表现为认知障碍(59.1%)和头痛(50.0%),其次为癫痫(36.4%)和抑郁状态(27.3%)。Anti-P阳性组患者认知障碍和抑郁发生率高于anti-P阴性组,但差异无统计学意义(P>0.05)。结论新疆地区anti-P阳性的青少年SLE患者发病年龄偏小,临床上更易出现关节炎和神经精神狼疮,病情活动度高,多伴有aCL抗体阳性,更多患者使用环磷酰胺治疗。

关键词(KeyWords)： 抗核糖体P蛋白;青少年;系统性红斑狼疮;神经精神狼疮;新疆

Abstract:

Keywords:

基金项目(Foundation): 新疆维吾尔自治区自然科学基金(2013211A094)

作者(Author): 赵春梅,刘慧,王彦焱,孟岩,古丽仙,张新玉,贾娜,罗莉

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