逼尿肌不稳定大鼠蛋白激酶C蛋白的表达Research the alteration of protein kinase C protein expression in detrusor instability rats
王军,崔玉霞,梁颖,庄仕华,李彤,宋波,金锡御,叶章群
摘要(Abstract)：
目的:探讨逼尿肌不稳定(DI)大鼠逼尿肌细胞蛋白激酶C(PKC)蛋白的表达及与DI的关系。方法:建立DI大鼠模型,原代培养DI与逼尿肌稳定(DS)大鼠膀胱逼尿肌细胞,应用Western-blotting方法检测培养细胞PKC蛋白的表达。结果:DI大鼠逼尿肌培养细胞PKC蛋白表达明显高于DS大鼠(P<0.01)。结论:DI大鼠逼尿肌细胞PKC蛋白表达明显升高,逼尿肌细胞PKC信号通路的改变与DI逼尿肌自发兴奋性升高可能有着密切联系。
关键词(KeyWords)： 蛋白激酶C;逼尿肌不稳定;大鼠
基金项目(Foundation):
作者(Author): 王军,崔玉霞,梁颖,庄仕华,李彤,宋波,金锡御,叶章群
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