张哲栋,孟蕾,靳路,傅松年

• 1:新疆医科大学第一附属医院
• 2:精河县人民医院

摘要(Abstract)：

目的 研究正念减压疗法(Mindfulness-based stress reduction, MBSR)对康复期精神分裂症患者的疗效及细胞炎性因子的影响，为康复期精神分裂症患者的临床治疗提供新的参考。方法 选取2021年6月-2022年6月于精河县人民医院精神卫生中心收治的150例康复期精神分裂症患者为研究对象，使用随机数字表法将其分为对照组和观察组，每组75例。对照组给予常规的药物治疗，观察组在常规治疗的基础上增加正念减压治疗方案，共8周。比较两组患者的临床总体印象量表(CGI)、焦虑自评量表(SAS)、抑郁自评量表(SDS)、汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、自我效能感量表(GSES)得分以及外周血白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)、肿瘤坏死因子(TNF-α)的水平。结果 治疗前，观察组和对照组患者的HAMA、HAMD、SAS、SDS、GSES得分及IL-6、IL-1β、TNF-α水平无明显差异。治疗8周后，两组患者的HAMA、HAMD、SAS、SDS得分及IL-6、IL-1β、TNF-α水平明显低于治疗前，GSES得分明显高于治疗前(P<0.05);治疗8周后，观察组患者的HAMA、HAMD、SAS和SDS评分及IL-6、IL-1β、TNF-α水平均明显低于对照组，观察组的自我效能感量表评分(GSES)高于对照组(P<0.05)。观察组的疗效明显优于对照组(P<0.05)。结论 正念减压疗法明显提升康复期精神分裂症患者的自我效能且有更好的疗效，并能减轻患者的抑郁和焦虑的严重程度及降低IL-6、IL-1β、TNF-α水平。

关键词(KeyWords)： 精神分裂症;正念减压疗法;抑郁;焦虑;炎性因子

Abstract:

Keywords:

基金项目(Foundation): 新疆维吾尔自治区卫生与健康适宜技术推广项目(SYTG-202152)

作者(Author): 张哲栋,孟蕾,靳路,傅松年

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