新疆医科大学学报

目的探讨抗角蛋白抗体(AKA)、抗环瓜氨酸肽抗体(CCP)、类风湿因子IgA、IgG、IgM抗体RF-IgA、RF-IgG、RF-IgM在临床诊断自身免疫性类风湿性关节炎(RA)中的临床意义。方法收集2009年4月～2010年1月新疆库尔勒市巴州人民医院门诊就诊患者的370份血清标本,采用间接免疫荧光法(IIF)和酶联免疫吸附法(ELISA)检测AKA、CCP、RF-IgA、RF-IgG、RF-IgM水平。选取符合临床RA诊断患者225例,对照组113例分析AKA、CCP、RF-IgA、RF-IgG、RF-IgM在不同性别、年龄RA患者中的分布情况。结果在225份检测标本中,AKA、CCP、RF-IgA、RF-IgG、RF-IgM的阳性率分别为15.1%、20.9%、31.6%、29.3%、30.7%,男女比例分别为1:2.8、1:3、1:2.9、1:3、1:2.5。不同性别各指标阳性率差异有统计学意义(P<0.01)。AKA、CCP、RF-IgA、RF-IgG、RF-IgM在不同年龄组间阳性率差异也有统计学意义(χ2=112.9,P均<0.01)。RA组和对照组AKA、CCP、RF-IgA、RF-IgG和RF-IgM阳性率差异也有统计学意义(P<0.01)。结论临床RA就诊患者中AKA、CCP、RF-IgA、RF-IgG、RF-IgM的阳性率在不同性别、年龄组间存在差异。

Objective To explore the positive distribution trend of general examine of Rheumatism in Rheumatism Arthritis(RA)and its significance in patients with RA.Methods The AKA,CCP,IgG,IgM,IgA in 370specimens were measured by indirect immunofluorescence(IIF)and enzyme linked immnosorbent assay(ELISA)form department of clinical laboratory,People Hospital of Bazhou of Xinjiang form April of 2009to January of 2010.The 225cases with RA patients were chosen.Meanwhile the control group was consist of 113cases.The positive distribution of AKA,CCP,RF-IgA,RF-IgG,RF-IgM in gender groups,age groups(≤25years old,26～50years old,≥51years old)and the values of the results for RA patients diagnosis were evaluated.Results Of the 225specimens,the positive rate of AKA,CCP,RF-IgA,RF-IgG,RF-IgM was 15.1%,20.9%,31.6%,29.3%,30.7%,the positive rates for male patients and female patients were 1:2.8,1:3,1:2.9,1:3,1:2.5.The positive rate in female patients was statistically higher than in male(χ2=113.76,P<0.01).In the different age group of≤25years old,26 ～50years old,≥51years old,there was statistical significance of AKA,CCP,RF-IgA,RF-IgG,RF-IgM positive rate(P<0.01).Conclusion The positive rate of AKA,CCP,RF-IgA,RF-IgG,RF-IgM in outpatients are different in term of gender and age.