新疆医科大学学报

目的探讨维吾尔医学(维医)异常黑胆质型与中医学髓海不足证的关系,为阿尔茨海默病(AD)的治疗提供新的途径。方法将202例纳入的AD患者按照维医辨证分型为异常黑胆质型、异常黏液质型、异常胆液质型、异常血液质型;按照中医学辨证分为髓海不足证、肝肾阴虚证、脾肾两虚证、心肝火旺证、痰浊阻窍证、气滞血瘀证,并以30例健康老人为正常组。采用酶联免疫吸附法(ELISA)测定血浆乙酰胆碱(Ach)、β-淀粉样蛋白1-40(Aβ1-40)、β-淀粉样蛋白1-42(Aβ1-42)含量。比较其中异常黑胆质型与髓海不足证之间的关系。结果(1)中医证型出现频率依次为髓海不足证(26.7%)>脾肾两虚证(21.3%)>气滞血瘀(17.8%)>肝肾阴虚证(13.9%)>心肝火旺证(10.4%)>痰浊阻窍证(10%);维医异常体液质出现频率依次为异常黑胆质型(53.9%)>异常黏液质型(20.3%)>异常胆液质型(13.3%)>异常血液质型(12.4%);(2)病例组Ach低于对照组,差异有统计学意义(P<0.05),而病例组Aβ1-40、Aβ1-42高于对照组,差异有统计学意义(P<0.05);(3)髓海不足证与异常黑胆质型Ach、Aβ1-40、Aβ1-42同正常组相比,差异均有统计学意义(P<0.05);(4)异常黑胆质型与髓海不足证在精神状态、面色肌肤、失眠多梦、烦躁、心神不宁、小便频数及脉象等方面具有一致性。结论异常黑胆质型与髓海不足证在AD患者中较为多见,二者可能是机体共同病理生理变化下的不同医学理论的结果,Ach是两者关于AD的沟通桥梁。

Objective To investigate the Abnormal Savda Testimony relationship with TCM marrow deficiency syndrome and provide a new treatment approach for this disease.Methods According to Uighur medicine syndrome,the 202 cases of AD including different Abnormal Savda types,such as bnoarmal mucus quality type,abnormal bile LC type,abnormal blood cytoplasmic;Divided according to traditional Chinese medicine syndrome marrow deficiency syndrome,liver kidney Yin deficiency,both spleen and kidney,heart and liver Huo syndrome,phlegmblocking orifices syndrome,blood stasis syndrome and 30 healthy elderly people is set to the normal group.Plasma Ach,β-amyloid and marrow deficiency syndrome between them.To compare the relationship between the Abnormal Savda type and the deficiency of the pulp sea.Results(1)The occurrence of TCM syndrome types of medullary sea deficiency syndrome(26.7%)>spleen and kidney deficiency syndrome(21.3%)>and qi stagnation and blood stasis(17.8%)>liver and kidney Yin deficiency syndrome(13.9%)>heart fire syndrome(10.4%)>phlegm turbidity resistance orifices(10%);(2)Ach cases lower than the control group,the difference was statistically significant(P <0.05),while A beta 1-40,A beta 1-42 case group is higher than the control group,the difference was statistically significant(P <0.05);(3)Lack of medullary sea card type and abnormalities savda,Ach,A beta1-40,A beta 1-42 compared with normal group,difference have statistical significance;(4)Abnormal Savda type and medullary sea deficiency syndrome in the mental state,skin complexion,not myself,be agitated,insomnia,pee frequency and pulse condition has consistency.Conclusion Abnormal Savda and marrow deficiency syndrome is more common in AD patients,and they may be the result of different medical theories common pathological physiological changes in the body under,Ach is their common bridge on the basis of AD.