新疆医科大学学报

目的探讨糖尿病肾脏损害的相关因素。方法将符合入选标准的168例2型糖尿病患者根据有无糖尿病肾病分为糖尿病肾病组(DN组,90例)和非糖尿病肾病组(非DN组,78例),DN组再分为DN早期组(62例)和DN中晚期组(28例),进行糖尿病肾脏损害的相关因素分析。结果 DN组与非DN组间空腹血糖、糖化血红蛋白、甘油三酯、总胆固醇、高密度脂蛋白、低密度脂蛋白、载脂蛋白a、载脂蛋白b比较差异无统计学意义(P>0.05);高血压、脂蛋白a和纤维蛋白原差异有统计学意义(P<0.05);内生肌酐清除率和尿微量白蛋白组间差异有统计学意义(P<0.01)。3组间比较,DN早期组与非DN组间脂蛋白a差异有统计学意义(P<0.01),但尿微量白蛋白(UAE)差异无统计学意义(P>0.05)。Logistic回归显示脂蛋白a是糖尿病肾病的危险因素,文化程度是糖尿病肾病的保护因素。结论脂蛋白a与糖尿病肾病损害程度密切相关,随着糖尿病肾病的加重,脂蛋白a进行性升高。脂蛋白a可以作为早期预测指标。

Objective To analyze the related factors of diabetic nephropathy.Methods According to whether the patients suffered from diabetic nephropathy or not,we divided the 168patients into 2groups(non-diabetic nephropathy group and nephropathy group)in order to analyze the related factors which may low down the renal function.Results The number of non-diabetic nephropathy patient is 78and the number of the diabetic nephropathy patient is 90.Between DN group and non-DN group,fasting plasma glucose(FPG),Glycohemoglobin A(HbA1C),triglyeride(TG),total cholesterol(TC),high-density lipoprotein HDL-C,low-density lipoprotein(LDL-C),ApoA,ApoB had no statistical disparity(P >0.05).LPa and FIB had statistical disparity between DN group and non-DN group(P <0.05).Ccr and UAE had significantly statistical disparity between DN group and non-DN group(P <0.01).Comparisons between three groups showed that LPa had significantly statistical disparity between earlier DN jm group and nonDN group(P <0.01),but UAE had no statistical disparity(P>0.05).Logistic return showed that LPa was hazards of DN.The protection of oneself depends on his cultural degree.Conclusion LPa takes part in the progress of DN,and is crossly-related with the extent of damage of DN,LPa is gradually increasing according to the extent of damage of DN.We could use LPa as early prediction index.