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目的:探讨基质金属蛋白酶 (MMP)家族成员中的 MMP- 2和 MMP- 9在鼻内翻性乳头状瘤和鼻息肉组织中的表达。方法:采用免疫组织化学方法检测 30例鼻内翻性乳头状瘤和 15例鼻息肉组织中 MMP- 2和 MMP- 9的表达。结果 :MMP- 2和 MMP- 9在细胞浆染色最强。鼻内翻性乳头状瘤组织和鼻息肉组织中 MMP- 2阳性表达率分别为 5 6 .6 7%和 4 6 .6 7% (χ2 =0 .4 0 2 ,P >0 .0 5 ) ,MMP- 9阳性表达均为 80 .0 0 %。结论:MMP家族所致的蛋白水解酶活性增高可能在鼻内翻性乳头状瘤对骨的破坏力上起主要作用。
Abstract：Objective: To investigate the expression of difference MMP-2 and MMP-9 of matrix metalloproteinases in nasal inverted papilloma(NIP). Methods: 30 NIP and 15 nasal polyps (NP) were studied with immunohistochemical LSAB (Labeled Streptavidim Biotin) method. Results: The results indicated that 56.67% cases of NIP were MMP-2 positive,and 80.00% cases of NIP were MMP-9 positive. Conclusion: MMP-2 and MMP-9 may play an important role in the development of NIP.
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基本信息:
中图分类号:R765
引用信息:
[1]郑艳,张华,王春利,丁军.基质金属蛋白酶在鼻内翻性乳头状瘤及鼻息肉组织中的表达[J].新疆医科大学学报,2004(04):399-400.
2004-08-30
2004-08-30