新疆医科大学学报

目的:探讨不同年龄段食管癌患者的临床和病理学特点。方法:对174例食管癌患者临床资料进行回顾性分析。174例患者中≤40岁(青年组)、41~46岁(中年组)、>60岁(老年组)患者分别为26、74、74例,分析比较各组的一般临床及病理学特点。结果:各年龄组食管癌患者的性别、民族构成及发病部位差异均无统计学意义(P>0.05)。老年组术前合并症及术后并发症发生率均明显高于青年组和中年组(P<0.05),随着年龄的增长,高、中分化所占的比例呈上升趋势,而低分化所占比例呈下降趋势,各组差异有统计学意义(P<0.05);青年组区域淋巴结转移率明显高于老年组(P<0.05);随着年龄的增长,临床TNM分期Ⅲ期以上者呈下降趋势,各组差异有统计学意义(P<0.05)。结论:不同年龄段食管癌临床、病理学特点存在明显差异,青年食管癌病情发展快,肿瘤分化程度低,区域淋巴结转移率高,TNM分期晚;而老年食管癌术前合并症多,术后并发症发生率高,但病情发展较慢,肿瘤分化程度高,区域淋巴结转移率低,TNM分期较早;中年食管癌居中。

Objective: To study the relationship between the pathological characteristic and clinical features of esophageal cancer in the different age group patients. Methods: To study clinical data of 174 patients with esophageal cancer. Among the 174 patients, there were 26 patients in the young age group (<40 y), 74 patients in the middle age group (41～60 y), 74 patients in the old age group (>60 y), respectively. To compare the clinical and pathological features in different age groups. Results: There were no significant difference (P>0.05) among the three groups when compared the sex, ethnic proportion, prevalence location of cancer. Compared with the other two groups, in the elder group pre-operative and post-operative complications were significantly higher than the other two groups (P<0.05). As the patients grow older,there were increasing tendency of the incidence of the highly differentiated cancer, decreased tendency of the incidence of the poorly differentiated cancer. There were significant statistical difference among three groups (P<0.05). As the patients grow older, there is decreasing tendency of clinical stage Ⅲ cancer , There were significant statistical differences among three groups (P<0.05). Conclusion: The pathological characteristic and clinical features of esophageal cancer among the different age group patients were different.