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目的探讨care HPV DNA初筛及细胞学检查分流在新疆宫颈癌筛查中的应用价值。方法对和田墨玉县6 000例女性进行care HPV及国产薄层液基细胞学检测,对任一一项结果阳性者召回行阴道镜检查及宫颈多点活检。分别对care HPV初筛、薄层液基细胞学分流及薄层液基细胞学初筛、care HPV分流2种方法进行诊断性试验评价,采用病理学为诊断金标准,计算出每种检查方法的灵敏度、特异度、阳性预测值及阴性预测值。结果以care HPV为初筛、薄层液基细胞学为分流的筛查方法 AUC值为0.743,高于以细胞学初筛、HPV分流法。结论 care HPV初筛、细胞学分流法在新疆农村地区妇女宫颈癌筛查中有较好的应用前景。
Abstract：Objective To evaluate the clinical value of TCT split-flow for HPV positive method on Xinjiang cervical cancer screening project. Methods Colposcopy and cervical biopsy were given to the women with positive result of the care HPV test and Thinprep test. Diagnostic evaluation was conducted to detect the sensitivity,specificity,predictive positive value and predictive negative value and the AUC. Diagnostic value was compared by ROC curve and analyzed by SPSS19. 0 software. Results It showed better value for the test of TCT split-flow for HPV positive result than HPV split-flow for TCT positive method,with their AUC 0. 743 and 0. 680 respectively. Conclusions Split-flow by TCT after screening by care HPV method showed high diagnostic value in Xinjiang cervical cancer screening.
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基本信息:
中图分类号:R737.33
引用信息:
[1]帕提曼·米吉提,唐努尔·阿布力米提,古扎丽努尔·阿不力孜,等.careHPV初筛及TCT分流法在新疆宫颈癌筛查中的应用[J].新疆医科大学学报,2015,38(04):389-393+399.
基金信息:
国家自然科学基金(81272335);; 新疆医科大学科研创新基金(XJC201375)
2015-04-15
2015-04-15