| 19 | 0 | 32 |
| 下载次数 | 被引频次 | 阅读次数 |
目的 明确银屑病患者血清正五聚蛋白3(PTX3)、胸腺活化调节趋化因子(TARC)表达特点，分析其与银屑病患者治疗效果之间的具体关系。方法 选取2020年1月至2023年12月期间于本院接受治疗的120例银屑病患者作为研究对象，根据治疗8周后疗效分为有效组(86例)和无效组(34例)。收集两组患者临床资料，分析治疗前血清PTX3、TARC与银屑病治疗效果的关系。结果 有效组和无效组银屑病患者的年龄、银屑病面积和严重程度指数(PASI)评分、超敏C反应蛋白(hs-CRP)、降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)、白细胞计数(WBC)、中性粒细胞计数、红细胞沉降率(ESR)、白细胞介素(IL-8)、PTX3、TARC水平以及病情程度差异有统计学意义(P均<0.05)。多因素Cox回归分析显示，PASI评分、PCT、TNF-α、IL-8、PTX3、TARC均为银屑病治疗无效的独立危险因素(P<0.05)。ROC曲线表明，PTX3(AUC=0.890)、TARC(AUC=0.860)对于银屑病患者治疗效果有较高的预测能力，且显著优于PCT(AUC=0.793)、PASI评分(AUC=0.836)、TNF-α(AUC=0.782)和IL-8(AUC=0.820),P<0.001。Kaplan-Meier曲线和Lowess曲线结果表明，随着PTX3、TARC表达水平增高，治疗有效率显著降低。危险度分析结果显示，银屑病PTX3、TARC高表达患者治疗后无效风险分别为低表达患者的1.122、1.325倍(P均<0.05)。结论 PTX3、TARC是银屑病治疗无效的独立危险因素，具有较好的预测价值，可作为潜在的临床早期诊断指标。
Abstract：Objective To clarify the expression characteristics of serum n-pentamerprotein 3(PTX3) and thymus activation-regulated chemokine(TARC) in patients with psoriasis, and to analyze the specific relationship between them and the therapeutic effect of psoriasis patients. Methods A total of 120 patients with psoriasis who were treated in the hospital from January 2020 to December 2023 were selected as research subjects. According to the treatment effect after 8 weeks of the treatment, the patients were divided into the effective group(86 cases) and the ineffective group(34 cases). Collected the clinical data of the patients and analyzed the relationship between serum PTX3, TARC and the therapeutic effect of the patients with psoriasis. Results The age, psoriasis area and severity index(PASI) score, high-sensitivity C-reactive protein(hs-CRP), procalcitonin(PCT), tumor necrosis factor(TNF-α), white blood cell count(WBC), neutrophil count, erythrocyte sedimentation rate(ESR), interleukin(IL-8) and positive of the patients with psoriasis in the effective group and the ineffective group. There were statistically significant differences in the levels of pentoxin-3(PTX3), thymus activation-regulated chemokine(TARC) and the severity of the disease(all P<0.05). Multivariate Cox regression analysis showed that PASI score, PCT, TNF-α, IL-8, PTX3 and TARC were all independent risk factors for ineffective treatment in patients with psoriasis(P<0.05). The ROC curve indicates that PTX3(AUC=0.890) and TARC(AUC=0.860) had a relatively high predictive ability for the therapeutic effect of the patients with psoriasis. And it was significantly superior to PCT(AUC=0.793), PASI score(AUC=0.836), TNF-α(AUC=0.782) and IL-8(AUC=0.820). The results of the Kaplan-Meier curve and the Lowess curve indicated that with the increase of the expression levels of PTX3 and TARC, the effective rate of treatment were decreased significantly. The results of risk analysis showed that the risk of ineffective treatment for the patients with high expression of PTX3 and TARC in psoriasis was 1.122 and 1.325 times that of the patients with low expression, respectively(all P<0.05). Conclusion PTX3 and TARC are independent risk factors for ineffective treatment in patients with psoriasis, with good predictive value and can be used as potential early clinical diagnostic indicators.
[1] MARONESE C A,VALENTI M,MOLTRASIO C,et al.Paradoxical psoriasis:An updated review of clinical features,pathogenesis,and treatment options[J].J Invest Dermatol,2024,144(11):2364-2376.
[2] CHIARI D,PIRALI B,PERANO V,et al.The crossroad between autoimmune disorder,tissue remodeling and cancer of the thyroid:The long pentraxin 3 (PTX3)[J].Front Endocrinol (Lausanne),2023,14:1146017.
[3] LI A,ZHAO F,YANG T,et al.PTX3/TWIST1 feedback loop modulates lipopolysaccharide-induced inflammation via PI3K/Akt signaling pathway[J].J Interferon Cytokine Res,2022,42(4):161-169.
[4] GUTTMAN-YASSKY E,KABASHIMA K,STAUMONT-SALLE D,et al.Targeting IL-13 with tralokinumab normalizes type 2 inflammation in atopic dermatitis both early and at 2 years[J].Allergy,2024,79(6):1560-1572.
[5] ZIJTREGTOP E A M,VANGER STRATE I,BEISHUIZEN A,et al.Biology and clinical applicability of plasma thymus and activation-regulated chemokine (TARC) in classical hodgkin Lymphoma[J].Cancers (Basel),2021,13(4):884.
[6] 张锡宝，张学军.中国银屑病诊疗指南(2018完整版)解读[J].中华医学信息导报，2019,34(22):23.
[7] 黄悦勤.医学科研中随机误差控制和样本量确定[J].中国心理卫生杂志，2015,29(11):874-880.
[8] 姚丹霓，何泽慧，谢秀丽，等.寻常型银屑病主症量表的信度、效度评价[C].杭州：世界中医药学会联合会皮肤科专业委员会.2015.
[9] ZHANG P,SU Y,LI S,et al.The roles of T cells in psoriasis[J].Front Immunol,2023,14:1081256.
[10] 史玉玲.《中国银屑病诊疗指南(2023版)》解读[J].同济大学学报(医学版),2023,44(5):631-633.
[11] 张辉，杜凡，李燕妮.寻常型银屑病患者血清脂质运载蛋白2,基质金属蛋白酶9水平与病情及预后的相关性分析[J].中国医刊，2024,59(11):1229-1232.
[12] CHEN C,CHE K,GUO Y,et al.Effect of the age of onset on epidemiology,clinical features,and comorbidity of geriatric psoriasis[J].J Dermatol,2023,50(9):1156-1161.
[13] 陈源，张晓慧，张卓莉.中性粒细胞与淋巴细胞比值血小板与淋巴细胞比值系统性免疫炎症指数评估司库奇尤单抗治疗银屑病关节炎疗效[J].中华风湿病学杂志，2024,28(7):452-459.
[14] TIMIS T L,BENI L,FLORIAN I A,et al.Prevalence of metabolic syndrome and chronic inflammation in psoriasis before and after biologic therapy:a prospective study[J].Med Pharm Rep,2023,96(4):368-383.
[15] ZHANG H,WANG Y,ZHAO Y,et al.PTX3 mediates the infiltration,migration,and inflammation-resolving-polarization of macrophages in glioblastoma[J].CNS Neurosci Ther,2022,28(11):1748-1766.
[16] MAN A M,OR?SAN M S,HOTEIUC O A,et al.inflammation and psoriasis:a comprehensive review[J].Int J Mol Sci,2023,24(22):16095.
[17] LIU J,QIU C,ZHOU Z,et al.Pentraxin 3 exacerbates psoriasiform dermatitis through regulation of macrophage polarization[J].Int Immunopharmacol,2024,130:111805.
[18] WU L T,QIAO Z H,TIAN J B,et al.The effect of secukinumab treatment for psoriasis on serum cytokines and correlation with disease severity[J].Skin Res Technol,2023,29(7):e13405.
[19] BAK S G,LIM H J,PARK E J,et al.Effects of Vigna angularis extract and its active compound hemiphloin against atopic dermatitis-like skin inflammation[J].Heliyon,2023,9(2):e12994.
[20] TANG Y,ZHANG X,WANG Y,et al.Dietary ellagic acid ameliorated clostridium perfringens-induced subclinical necrotic enteritis in broilers via regulating inflammation and cecal microbiota[J].J Anim Sci Biotechnol,2022,13(1):47.
[21] LIU B X,XIE Y,ZHANG J,et al.SERPINB5 promotes colorectal cancer invasion and migration by promoting EMT and angiogenesis via the TNF-α/NF-κB pathway[J].Int Immunopharmacol,2024,131:111759.
[22] MACPHERSON M L,GIGUèRE S,POZOR M A,et al.Evidence for anti-inflammatory effects of firocoxib administered to mares with experimentally induced placentitis[J].Am J Reprod Immunol,2021,86(1):e13396.
[23] BEVELACQUA V,LIBRA M,MAZZARINO M C,et al.Long pentraxin 3:a marker of inflammation in untreated psoriatic patients[J].Int J Mol Med,2006,18(3):415-423.
[24] 吴敏，刘涛峰，刘小平，等.复方泽漆冲剂通过抑制NLRP3炎症小体活化改善咪喹莫特诱导银屑病样小鼠的作用及机制研究[J].中药新药与临床药理，2023,34(11):1551-1558.
[25] GR?N F,KERSTAN A,SERFLING E,et al.Current developments in the immunology of psoriasis[J].Yale J Biol Med,2020,93(1):97-110.
基本信息:
中图分类号:R758.63
引用信息:
[1]杨林洪,董美丽,夏利.血清PTX3、TARC与银屑病治疗效果的关系[J].新疆医科大学学报,2025,48(08):1109-1115.
基金信息:
广西壮族自治区卫生健康委员会自筹经费科研项目(Z20210893)
2025-08-15
2025-08-15