新疆医科大学学报

目的对维吾尔族长寿老人进行维医体液辨证分型并进行Altheimer Disease(AD)病的诊断,查找不同体液型中AD患病分布趋势,探讨不同体液在AD的发病中所发挥的作用,从而为AD的维医辨证施治、药物干预提供依据。方法对新疆莎车县随机收集的维吾尔族90岁以上长寿老人共计200例进行维医体液辨证分型,并通过神经心理评估及相关神经系统检查诊断长寿人群中的AD病例。结果 200例长寿老人中AD患者占21.5%(43例),未罹患AD者(非AD)占78.5%(157例);原体液质以血液质和粘液质气质为主,黑胆质型体液者AD所占比例最高,血液质体质者所占比例最少,差异有统计学意义(P<0.01);异常体液的生成以异常黑胆质体液为主,占50.5%(101例),达50%以上;异常黑胆质体液生成者在AD人群中所占比例最高,异常血液质者中AD发病最少,不同异常体液质的生成在健康长寿和AD患者中所占比例差异有统计学意义(P<0.01)。结论长寿人群原体液类型为血液质及粘液质体液;长寿人群中生成的异常体液类型为异常黑胆质体液;异常黑胆质体液是长寿人群中AD患者的主要致病体液类型。

Objective To diagnose Alzheimer′s disease among the Uyghur elders with longevity subtyping the humoral type of elders in traditional Uyghur medical way,finding out the distribution of AD disease tendency in different Hilit type,exploring the role of different Hilits in the onset of AD to provide evidence in a Uyghur medical way of syndrome differentiation and treatment for AD with pharmacological intervention.Methods A total of 200 Uyghur people with longevity who aged 90 and older were collected in Yakhan,Xinjiang.Subtyping in types of hilit was performed,and the AD cases were diagnosed among the longevous through neural-psychological assessment and neurologic examination.Results Among the 200 cases,AD patients accounted for 21.5%(43 cases)of the total,elder people with longevity who did not suffer from AD accounted for 78.5%(157 cases)of the total; The primordial hilit was mainly predominated by Kan hilit,phlegm temperament.Longevous with Savda hilit type has the highest proportion in AD cases while Kan hilit type has the lowest proportion in AD cases.This difference was statistical-ly significant.Abnormal humoral production mainly predominated by abnormal savda hilit,accounting for 50.5%(101 cases),reaching more than 50%.The producer of abnormal savda hilit holds the highest percentage in AD cases.However,the Kan hilit type carrier has the lowest chance of morbidity on AD cases.The percentage difference on the abnormal humoral production which associated with those healthy elderly and those AD patients became statistically significant.Conclusion The primordial hilit of the longevity crowd were mainly Kan hilit and Phelgmhilit;the abnormal humoral production of longevity crowed was abnormal savda hilit;abnormal savda hilit was the main pathogenic humoral type which causes AD.