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目的探讨新疆维吾尔族2型糖尿病(T2DM)的危险因素及其与胰岛素生长因子1(IGF-1)的关系。方法选取2013年10月-2014年5月新疆医科大学第一附属医院确诊为T2DM的维吾尔族患者171例作为病例组,选择同期于该院进行体检的非T2DM者199例作为对照组。对所有纳入对象进行问卷调查及生化检查和血清IGF-1检测。结果病例组与对照组的不同来源地、吸烟、喝酒、糖尿病家族史、糖化血清蛋白、TG、TC、HDLC、LDL-C、尿酸、IGF-1的差异有统计学意义(P<0.05);多因素Logistic回归分析显示来源地、喝酒、糖尿病家族史为危险因素(P<0.05);文化程度、IGF-1为保护性因素(P<0.05)。结论血脂代谢紊乱、尿酸升高、家族史、喝酒、文化程度低、IGF-1降低是维吾尔族患2型糖尿病的危险因素。IGF-1是2型糖尿病的新型预测指标,值得进一步深入研究。
Abstract：Objective To find the risk factors and the relationship between them and IGF-1in Uyghur patients with type 2diabetes(T2DM).Methods 171 Uyghur patients of the First Affiliated Hospital of Xinjiang Medical University from October 2013 to May 2014 who confirmed T2 DM were assigned into case group,another 199 people who had medical examination in the same hospital but showed the normal range of blood sugar levels during the same period were selected as the control group.All the subjects finished questionnaire and received biochemical examination and serum IGF-1detection.Results There were significant differences between the two groups in sources,smoking,drinking,stress,glycosylated serum protein,TG,HDL-C,uric acid,IGF-1(P <0.05);multivariate logistic regression analysis showed that the source of the value of ORwas 2.255(95%CI1.309-3.885),family history of diabetes ORvalue was2.589(95%CI 1.305-5.315)and drinking as risk factors.The education degree,the value of OR was0.555(95%CI0.319-0.968),IGF-1 OR0.194(95%CI0.067-0.561)were identified as protective factors.Conclusion Dyslipidemia,elevated uric acid,family history,drinking,low education level,IGF-1reveal the risks to develop type 2diabetes in Uyghur people.IGF-1is model prediction index,which is worthy of further study.
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基本信息:
中图分类号:R587.1
引用信息:
[1]王婷婷,江艳,慧瑜,等.新疆维吾尔族居民2型糖尿病危险因素及其与胰岛素生长因子1的关系[J],2014,37(10):1249-1252.
基金信息:
国家重点基础研究发展计划(973计划)(2012CB722403);; 新疆重大疾病医学重点实验室开放课题(SKLIB-XJMDR-2012-Y4);; 新疆医科大学研究生科研创新基金(XJGRI2013083);; 新疆医科大学公共卫生学院大学生创新课题