新疆医科大学学报

目的:探讨肿瘤标志物甲胎蛋白(AFP)、L-岩藻糖苷酶(AFU)、谷氨酰转肽酶(GGT)、5′-核苷酸(5′-NT)在原发性肝癌(PHC)诊断中的应用价值。方法:110例分为2组,PHC组70例,正常对照组40例,采用电化学发光仪检测2组血清AFP水平,采用LX-20型生化仪检测2组AFU、GGT、5′-NT水平,并分析4种肿瘤标志物对PHC的诊断价值。结果:PHC组血清AFP、AFU、GGT、5′-NT水平均明显高于正常对照组,差异有统计学意义(P<0.05-0.01)。AFP、GGT、5′-NT、AFU对PHC诊断的敏感性分别为71.42%、68.57%、32.86%、21.43%,AFU、GGT、5′-NT检测的特异性均为100.00%,AFP检测特异性为95.00%,4种血清肿瘤标志物联合检测敏感性为92.85%。结论:肿瘤标志物AFP、AFU、GGT、5′-NT对PHC有一定的诊断价值,4种肿瘤标志物联合检测可提高诊断PHC的敏感性。

Objective: To probe the diagnostic value of al-fetoprotein(AFP), a-L-fucosidase(AFU), r-glu-tamyl transpeptidase(GGT) , 5'nucleotidase(5'-NT) for primary hepatocellular larcinoma (PHC). Methods: One hundred and ten case were divided into PHC group and normal control group. Electrochem cumi-nescence method was used to detect serum AFP, LX-20 biochemical instrument for AFU, GGT and 5' -NT of these two groups. Results: The serum level of AFP, AFU, GGT and 5'-NT in PHC group were significantly higher than that of in control group (P <0. 05-0. 01). The sensibility of AFP, GGT, 5'-NT and AFU for PHC were 71. 42%, 68. 57%, 32. 86% and 21. 43%. The specificity of AFU, GGT, 5'-NT, AFU were 100. 00%, 100. 00%, 100. 00%, 95. 00%, respectively. The sensibility of these four tumor markers was 92. 85%. Conclusions: These four tumor marker have some diagnostic value for PHC.