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目的 分析本市4 408例健康体检者幽门螺杆菌(Helicobacter pylori,Hp)感染状况，并探讨与血脂异常的相关性。方法 采用13C-尿素呼气试验法检测幽门螺杆菌的感染状况，同时收集研究对象的人口学资料和血脂四项指标结果，比较Hp感染组和Hp未感染组血脂异常的差异。分层分析Hp感染组和Hp未感染组血脂异常率的差异，并进行Logistic回归分析，探讨Hp感染与血脂异常的关系。结果 4 408例健康体检者中Hp的感染率为35.62%,Hp感染率随年龄增加而增高，男性Hp感染率高于女性，差异有统计学意义（P<0.05）,Hp感染组总胆固醇和甘油三酯均高于未感染组，且差异具有统计学意义（P<0.05）。分层分析发现，男女性别中Hp感染组血脂异常率均高于Hp未感染组，差异有统计学意义（P<0.05）；而在年龄分层中，51～60岁组别中，血脂异常率在Hp感染组和Hp未感染组间差异有统计学意义（P<0.05）；在体质指数分层中，超重组和肥胖人群中Hp感染组的血脂异常率均显著高于Hp未感染组，差异具有统计学意义（P<0.05）。多元Logistic回归分析显示，年龄、性别、总胆固醇和低密度脂蛋白异常是Hp感染的影响因素。结论 Hp感染与年龄和性别有关，并且可能影响血脂异常的发生率。
Abstract：Objective To investigate the relationship between Helicobacter pylori(Hp) infection and dyslipidemia in4408 health examination population. Methods The infection status of Helicobacter pylori was detected by13C-urea breath test, and the demographic data and the results of four blood lipid indexes of the subjects were collected. The differences of dyslipidemia between the Hp infected group and the Hp uninfected group were compared. The difference of dyslipidemia rate between the Hp infection group and the non-Hp infection group were analyzed by stratification, and binary logistic regression analysis was conducted to explore the relationship between the Hp infection and dyslipidemia. Results The infection rate of Hp in 4408 healthy people in Urumqi was 35.62%. The infection rate of Hp was increased with age. The infection rate of Hp in males was higher than that in females(P<0.05); total cholesterol and triglyceride in Hp infected group were higher than those in non-infected group(P<0.05). Stratification analysis showed the rates of dyslipidemia in the Hp infected group were higher than those in the Hp uninfected group(P<0.05); In age stratification, there was a statistically significant difference in dyslipidemia rates between Hp-and non-Hp-infected groups(P<0.05); In stratification of body mass index, the rate of dyslipidemia was significantly higher in the Hp infection group and the obese group than in the Hp non-infection group(P<0.05). Logistic regression analysis showed that age, sex, total cholesterol and low density lipoprotein abnormalities were risk factors for Hp infection. Conclusion Hp infection is related to age and sex, and it may affect the incidence of dyslipidemia.
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基本信息:
中图分类号:R573
引用信息:
[1]李鲁,刘涛,邹媛,等.4408例体检者幽门螺杆菌感染与血脂异常的相关性分析[J].新疆医科大学学报,2022,45(03):351-355.
基金信息:
新疆维吾尔自治区科技创新基地建设（资源共享平台建设）项目（PT-2019）; 国家自然科学基金地区基金项目(81860510); 省部共建国家重点实验室精准医学专项项目(SKL-HIDCA-2020-JZ2)
2022-03-15
2022-03-15