新疆医科大学学报

目的:探讨瘦素(Leptin)水平与高尿酸血症相关关系。方法:从2007年1～7月新疆医科大学附属中医医院住院病人中筛选出400例为研究对象,其中高尿酸血症组190例,正常组为同期该院的无高尿酸血症及痛风、无血缘关系及年龄性别构成无差别者210例。分别检测一般身体指标及生化指标。通过现场问卷完成研究对象的一般情况、疾病史的调查,采用ELISA酶联免疫法检测血清Leptin水平。结果:高尿酸血症组血清尿酸(SUA),甘油三酯(TG),高密度脂蛋白(HDL-C)及体重、体质指数(BMI)与正常组相比差异均有统计学意义,其中除HDL-C外均为高尿酸血症组高于正常组(P<0.05),Leptin与收缩压(SBP)、舒张压(DBP)、BMI、SUA均呈正相关。结论:Leptin参与代谢紊乱的病理机制,与代谢综合征指标密切相关,可能是高尿酸血症、肥胖、血脂异常等代谢综合征的共同发病基础。

Objectives:To study the relationship between hyperuricemia and Leptin.Methods:The 400 samples were collected from January to July 2007 in the affiliated Chinese medicine hospital,divided them into two groups:hyperuvicemia group(190 cases),control group(210 cases),measured the indexes including height,body weight,BMI,blood pressure and analyze the SUA,TG,TC,HDL-C,LDL-C,VLDL-C,use ELISA to detect the serum Leptin.Results:The indexes of SUA,TG,body weight and BMI increased and HDL-C had decreasing trend between hyperuricemia and control group.There are correlation between Leptin and SBP,DBP and BMI.Conclusions:Leptin participate in metabolic disorder and correlated with some indexes of metabolism syndrome.Leptin may be a part in the cause of hyperuricemia,obesity and metabolic disorder.