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目的探讨新疆和田地区维吾尔族长寿老人血浆血管紧张素Ⅱ、醛固酮及生化代谢等指标的变化。方法随机抽取100例自然长寿老人(≥90岁)(长寿组)和106例(65～70岁)老年人(老年组),测定血浆血管紧张素Ⅱ、醛固酮、血脂、血糖、胰岛素、血肌酐、尿肌酐、血尿酸及尿液电解质水平。结果 (1)长寿组的血管紧张素Ⅱ高于老年组,而醛固酮则低于老年组,两组间比较差异均有统计学意义(P<0.05)。(2)长寿组空腹血糖、血胰岛素、胰岛素抵抗指数、甘油三酯均低于老年组,而长寿组总胆固醇、高密度脂蛋白胆固醇均高于老年组,两组比较除空腹血糖外均有显著性差异统计学意义(P<0.05),长寿组和老年组血肌酐未见明显差异(P>0.05),但长寿组老人尿肌酐和血尿酸均高于老年组(P<0.05)。(3)长寿组的尿钾高于老年组(P<0.05),尿比重低于老年组(P<0.05),两组尿钠和尿pH未见明显差异(P>0.05)。结论血管紧张素Ⅱ增高、醛固酮降低的分离现象,总胆固醇、高密度脂蛋白胆固醇相对增高及尿钾水平相对较高是该地区长寿老人的特征。
Abstract：Objective To explore the reason of longevity among Uygur natural longevous people in Hetian through the measure and analysis of angiotensin Ⅱ,aldosterone and other biochemical metabolism indicators of laboratory tests.Methods The longevous people aged ≥90 years old(n=99) were verified by systematic investigation,and Uygur old people aged 65~70 years old(n=106) were selected with cluster sampling from Hetian,angiotensin Ⅱ,aldosterone,blood lipids,blood glucose,insulin,serum creatinine,urine creatinine,serum uric acid and urine liquid electrolyte were measured in.Results(1) The plasma levels of AT-Ⅱ in the natural longevous people were higher than those of the Uygur old people group,but the aldosterone levels of the longevous were lower than those of the old people(P<0.05).(2) Longevity group′s fasting blood glucose,plasma insulin,insulin resistance index,triglycerides were lower than the older group,and the longevity of the group total cholesterol,high density lipoprotein cholesterol,urine creatinine and serum uric acid were higher than the older group,with the differences were statistically significant(P<0.05),except the fasting blood glucose.(3) Longevity group′s centenarians urinary potassium was higher than that of the older group(P<0.05);centenarians group urine specific gravity was lower than the older group(P<0.05);centenarians group and the older group urinary sodium and urine PH were no significant differences(P>0.05).Conclusion The separation phenomenon with angiotensin Ⅱ increased and aldosterone reduced,relatively higher level of the total cholesterol,high density lipoprotein cholesterol and the urinary potassium are all the characteristics of the Uygur natural longevous people in Hetian.
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基本信息:
中图分类号:R54
引用信息:
[1]韩璐,徐新娟,梁晓慧,等.新疆和田维吾尔族自然长寿老人血管紧张素Ⅱ、醛固酮及生化代谢等指标的检测与分析[J].新疆医科大学学报,2011,34(10):1055-1059.
基金信息:
国家自然科学基金项目(30860296)
2011-10-15
2011-10-15