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骆驼蓬总生物碱,经临床验证能改善消化道肿瘤病人的临床症状。本文用骆驼蓬总生物碱注射液,依据大多数药物的血药浓度和药效、毒性呈平行关系这一原理。采用药物累积法,把药物动力学中血药浓度多点动态测定的原则与动物急性死亡率测定蓄积性的方法结合起来。以小鼠急性死亡率机率单位作为分级定量的药理效应指标,通过剂量效应曲线,转换成相应的体内药物水平。以了解骆驼蓬总碱注射液在动物体内的代谢规律,并推算其主要动力学参数,供临床用药参考。
Abstract：The general alkaloid of peganum could improve the clinical symptom of the cancer of the digestive tract. According to the principle that the plasma concentration, drug-effect and toxicity of most drugs are correlated, we combined the rule of the measurement of plasmaconcentration (in pharmacokineties) with the method of calculation of acute mortality of mice by means of drug-accumulation. Then using the probit of acute mortality of mice act as the index of pharmacological effect. The dose-effect curve was converted into the corresponding level in the body so that we conld know the metabolic rule of peganum alkaloid in body, calculate the main pharmacokinetic parameters and provide reference for clinical use.
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基本信息:
引用信息:
[1]郑立明,刘得玺,孙殿甲.骆驼蓬总生物碱注射液毒性及药效学初步研究[J].新疆医学院学报,1988(03):179-181+178.
1988-09-30
1988-09-30