新疆医科大学学报

目的系统评价抗生素联合热毒宁治疗儿童社区获得性肺炎的临床研究。方法采用Cochrane系统评价方法,检索万方、维普、中国期刊全文、中国生物医学文献和Pubmed、Embase等中英文数据库,同时手工检索相关资料和网络信息,对纳入的资料进行Meta分析。结果最终纳入8篇研究,共2 451例患者。Meta分析结果显示:与单用抗生素组相比,联合用药组在总有效率(OR=4.83,95%CI[2.9,6.62],P<0.000 01)、退热时间(WMD=-1.61,95%CI[-2.13,-1.08],P<0.000 01)、缩短住院时间(WMD=-1.84,95%CI[-2.12,-1.57],P<0.000 01),不良反应发生率(OR=1.35,95%CI[0.72,2.54],P=0.36)等方面更具优势,差异有统计学意义。结论当前证据显示,抗生素联合热毒宁治疗儿童社区获得性肺炎具有一定优势,但研究存在偏倚的可能性,结论尚需更多高质量的多中心、大样本的随机双盲对照试验加以验证。

Objective To systematically evaluate the clinical study of antibiotics combined with Reduning in the treatment of children with community acquired pneumonia. Methods Cochrane systematic evaluation was used to retrieve the related literatures from database such as WanFang,VIP, CNKI, CBM, Pubmed, EMBASE and other Chinese and English databases. Finally, meta-analysis was performed on the included data. Results A total of 8 clinical RCTs involving 2 451 patients were included after exclusion. Meta-analysis showed that, compared with the control group, the test group had obvious advantages in the total effective rate(OR=4.83,95%CI[2.9,6.62],P<0.000 01), the antifebrile time(OR=4.83, 95%CI [2.9, 6.62], P<0.000 01), Shortening the hospital stay(WMD=-1.84,95%CI[-2.12,-1.57],P<0.000 01), the incidence of adverse reactions(OR=1.35,95%CI[0.72,2.54],P=0.36), and other aspects, with statistical difference being significant. Conclusion Current evidence suggests that antibiotics combined with Reduning in the treatment of children with community acquired pneumonia, has certain advantages. However, due to the possibility of bias in the study, So much more high-quality multicenter, large sample, randomized, double-blind, controlled trials were required to verify the conclusion drew here.