新疆医科大学学报

目的 探讨急性高甘油三酯血症胰腺炎(HTG-AP)患者血清白细胞介素-17(IL-17)、核因子-κB(NF-κB)水平与病情进展的关系。方法 选取2021年10月-2024年8月长沙市中医医院(长沙市第八医院)HTG-AP患者142例，均检测血清IL-17、NF-κB水平和统计HTG-AP患者病情进展情况，分析HTG-AP患者病情进展的影响因素及IL-17、NF-κB与HTG-AP患者病情进展的关系。结果 142例HTG-AP患者中有41例进展为SAP,发生率为28.87%(41/142),纳入SAP组，其余101例中MAP 56例，MSAP 45例，纳入NSAP组。SAP患者血清IL-17、NF-κB水平高于MSAP和MAP患者，MSAP患者IL-17、NF-κB水平高于MAP患者(P<0.05)。SAP组患者血清IL-17、NF-κB水平高于NSAP组患者(P<0.05)。血清IL-17、NF-κB水平与HTG-AP患者病情程度呈正相关(P<0.05)。血清IL-17、NF-κB水平联合预测HTG-AP患者病情进展的曲线下面积(AUC)值大于单一指标的预测值(P<0.05)。结论 无论是否调整混杂因素，血清IL-17、NF-κB水平升高均会增加HTG-AP患者病情进展风险。血清IL-17、NF-κB有望作为预测患者病情进展情况的潜在指标。

Objective To investigate the relationship between serum levels of interleukin-17(IL-17), nuclear factor-κB(NF-κB) and disease progression in patients with acute hypertriglyceridemic pancreatitis(HTG-AP). Methods A total of 142 patients with HTG-AP in the hospital from October 2021 to August 2024 were selected, and serum levels of IL-17 and NF-κB were detected. The influencing factors of disease progression in HTG-AP patients and the relationship between IL-17, NF-κB and disease progression in HTG-AP patients were analyzed. Results Among the 142 HTG-AP patients, 41 cases progressed to severe acute pancreatitis(SAP), with an incidence of 28.87%(41/142), and the patients were included in the SAP group; among the remaining 101 cases, 56 cases were MAP and 45 cases were MSAP. Serum levels of IL-17 and NF-κB in SAP patients were higher than those in MSAP and MAP patients, and the levels of IL-17 and NF-κB in MSAP patients were higher than those in MAP patients(P<0.05). The serum levels of IL-17 and NF-κB in SAP group were higher than those in NSAP group(P<0.05). Serum levels of IL-17 and NF-κB were positively correlated with the severity of HTG-AP patients(P<0.05). The AUC value of serum IL-17 and NF-κB combined to predict the disease progression of HTG-AP patients was greater than that of single index(P<0.05). Conclusion Elevated serum levels of IL-17 and NF-κB were increased the risk of disease progression in HTG-AP patients with or without adjusting for confounders. Serum levels of IL-17 and NF-κB are expected to be used as potential indicators to predict the disease progression of the patients.