新疆医科大学学报

目的：观察中分子物质（ＭＭＳ）对急性肝功不全动物发病的影响和肠道吸附剂的保护效应。方法：用１０％ Ｄ－氨基半乳糖生理盐水腹腔注射造成大鼠急性肝功不全实验模型，将肠道吸附剂混于食物中饲喂２ｄ，再腹腔注射１０％ Ｄ－氨基半乳糖作为处理组，同时设对照组。测定肝功能指标、ＭＭＳ变化，并进行肝组织电镜观察。结果：所有检测指标数值急性肝功不全组比对照组明显增加（Ｐ＜ ０．０５～０．０１），除γ－谷氨酰转肽酶（γ－ＧＴ）外，其余指标数值在处理组明显降低（Ｐ＜ ０．０５～０．０１），电镜下见到急性肝功不全组组织超微结构有改变，而处理组却有所减轻。结论：ＭＭＳ参与大鼠急性肝功不全的发病，肠道吸附剂有保护效应。因此，ＭＭＳ的变化可作为临床判断病情和估计预后的一个指标

Objective: Role of middle molecular substances (MMS) and protective effect of enterosorbent were studied in acute hepatic insufficiency in rats. Methods: 10%galactosamine (D GalN) normal saline 12 ml/kg were administered intraperitoneally to induce acute hepatic insufficiency (AHI) as experimental group. Before 10%GalN administered rats were fed with enterosorbent (>lg/kg/d), mixed and foraged two days as treatment group. The liver function and MMS were examined. The liver tissue was also observed under the electron microscope (EM). Results: II index levels were higher in AHI group than control group (P<0.05～0.01). Except γ GT the others were lower in treated group than AHI group (P< 0.05～0.01). The ultrastructure of liver tissue was changed in AHI group, but was less in treated group. Conclusion: MMS could participate in the pathogenesis of AHI and enterosorbent could have a protective effect.